Regenerative Biotechnology
Muse Cells
Stress-resistant multilineage differentiated cells for systemic regenerative therapy.
Muse cells have demonstrated efficacy as supportive therapy in conditions that benefit from regenerative potential, including acute myocardial infarction (reduction of infarct size and improved ventricular function), cardiac ischemic damage, ischemic stroke (neuronal regeneration and functional recovery), epidermolysis bullosa (dermal repair and collagen synthesis), cirrhosis, amyotrophic lateral sclerosis (neuroprotection and motor improvement), severe COVID-19 respiratory distress syndrome, and severe pancreatitis.
Composition
Stress-resistant multilineage differentiated cells.
Pharmaceutical form
Injectable solution.
Presentation
Single-dose vial, 4 ml.
Therapeutic properties
Non-tumorigenic endogenous pluripotent cell subpopulation with stress resistance, homing capacity to damaged tissues, spontaneous differentiation, secretion of regenerative cytokines, and immune privilege allowing allogeneic administration.
- Selective migration to injured tissues.
- Spontaneous differentiation into tissue-specific cells.
- Replacement of necrotic and apoptotic cells.
- Reduction of tissue inflammation.
- Inhibition of fibrosis.
- Stimulation of angiogenesis.
- Structural tissue repair.
- Prolonged immunological stability.
Mechanism of action & Clinical data
They recognize damaged tissues via S1P-SDF1α signaling, migrate to injury sites, differentiate spontaneously, and secrete regenerative, anti-inflammatory, and immunomodulatory cytokines.