Regenerative biotechnology
Muse Cell
Stress-resistant differentiated multilineage cells for systemic regenerative therapy.
Muse cells have shown efficacy as adjuvants in pathologies that benefit from regenerative potential such as acute myocardial infarction (reduction of infarct area and improved ventricular function), ischemic cardiac damage, ischemic stroke (neuronal regeneration and functional recovery), epidermolysis bullosa (dermal repair and synthesis of collagen VII/XVII), amyotrophic lateral sclerosis (neuroprotection and reduced muscle atrophy), spinal cord injury (motor improvement), and chronic nephropathies (reduction of fibrosis and parenchymal regeneration), acute respiratory distress syndrome due to COVID-19 and severe pancreatitis (reduction of proinflammatory cytokines and necrosis), and neonatal hypoxic-ischemic encephalopathy (neuroprotection and preservation of the blood-brain barrier).
Composition
Stress-resistant differentiated multilineage cells.
Pharmaceutical form
Injectable solution.
Presentation
Monovette with 4 ml.
Therapeutic Properties
Endogenous non-tumorigenic pluripotent cellular subpopulation with stress resistance, homing to damaged tissues, spontaneous differentiation, secretion of regenerative cytokines, and immune privilege that allows allogeneic administration.
- Selective migration to injured tissues.
- Spontaneous differentiation into cells of the affected tissue.
- Replacement of necrotic or apoptotic cells.
- Reduction of tissue inflammation.
- Inhibition of fibrosis.
- Stimulation of angiogenesis.
- Structural tissue repair.
- Prolonged immunological stability.
Mechanism of action & Clinical data
They recognize damaged tissues via sphingosine-1-phosphate, migrate to the site of injury, spontaneously differentiate, and secrete regenerative, anti-inflammatory, and immunomodulatory cytokines.